![]() The FMD was lower in the abacavir- treated patients than those not on abacavir (2.8% vs. Overall, the median FMD in the HIV-infected patients was low (3.5% IQR 2.3–5.6%). ![]() Thirty subjects (49%) were receiving abacavir. The median duration of HIV infection was 18 years, and the median CD4 cell count was 369 cells/mm3. Results The median age was 50 years (IQR 45–57). We compared FMD in patients treated with or without abacavir, while adjusting for traditional risk factors and HIV-specific characteristics. Endothelial function was assessed by measuring flow-mediated vasodilation (FMD) of the brachial artery. Methods We studied a cohort of 61 antiretroviral- treated patients who had undetectable plasma HIV RNA levels. As endothelial dysfunction is central to the pathogenesis of atherosclerosis, we tested the hypothesis that current treatment with abacavir is associated with impaired endothelial function. Abacavir has been associated with increased risk of cardiovascular events, for reasons that remain to be elucidated. Ganz, Peter Deeks, Steven G.īackground HIV-infected patients have accelerated atherosclerosis. Hatano, Hiroyu Xie, Yu Martin, Jeffrey N. Wu, Yuaner Schnell, Amanda Ho, Jennifer E. ![]() Association of Abacavir and Impaired Endothelial Function in Treated and Suppressed HIV-Infected Patients
0 Comments
Leave a Reply. |